![]() In addition to descriptive statistics, marginal posterior densities for each variable of interest were determined and a Monte Carlo pseudosample was generated with random draws obtained from the Student's t-distribution to assess, with inferential statistics, differences in variables of interest.īuspirone was evaluated in one flexibly dosed (N = 227) and one fixed-dose (N = 341) trial in children and adolescents aged 6-17 years with a primary diagnosis of GAD. Prospective, randomized, parallel-group controlled trials of buspirone in pediatric patients with GAD as well as associated pharmacokinetic studies were identified and data were extracted. With this in mind, we sought to present and validate a Bayesian approach for the reanalysis of summary data in abandoned clinical trials and to review and re-evaluate available pharmacokinetic, tolerability, and efficacy data from two large, randomized controlled trials of buspirone in pediatric patients with generalized anxiety disorder (GAD). You may report side effects to FDA at 1-80.An increasing number of abandoned clinical trials have forestalled efforts to advance the evidence base for the treatment of mood and anxiety disorders in children and adolescents. Call your doctor for medical advice about side effects. This is not a complete list of side effects and others may occur. Get emergency medical help if you have any signs of an allergic reaction to buspirone: hives difficult breathing swelling of your face, lips, tongue, or throat.Ī light-headed feeling, like you might pass out.Ĭommon buspirone side effects may include: Discuss the use of grapefruit products with your doctor. Grapefruit and grapefruit juice may interact with buspirone and lead to unwanted side effects. Be careful if you drive or do anything that requires you to be alert.ĭrinking alcohol may increase certain side effects of buspirone. This medication may impair your thinking or reactions. Seek emergency medical attention or call the Poison Help line at 1-80. Do not take extra medicine to make up the missed dose. Skip the missed dose if it is almost time for your next scheduled dose. Take the missed dose as soon as you remember. ![]() Store at room temperature away from moisture, heat, and light. Tell any doctor who treats you that you are using buspirone. You may need to stop using the medicine for at least 48 hours before your test. This medication can cause false positive results with certain medical tests. Some anxiety medications can cause withdrawal symptoms when you stop taking them suddenly after long-term use. If you have switched to buspirone from another anxiety medication, you may need to slowly decrease your dose of the other medication rather than stopping suddenly. Follow your doctor's instructions about how much of the tablet to take. Do not use a tablet if it has not been broken correctly and the piece is too big or too small. Some buspirone tablets are scored so you can break the tablet into 2 or 3 pieces in order to take a smaller amount of the medicine at each dose. You may take buspirone with or without food but take it the same way each time. Do not take this medicine in larger or smaller amounts or for longer than recommended. Your doctor may occasionally change your dose to make sure you get the best results. Follow all directions on your prescription label. Take buspirone exactly as it was prescribed for you. Tell your doctor if you are breast-feeding a baby.īuspirone is not FDA-approved for use by anyone younger than 18 years old, but this medicine has been used in children and adolescents under close medical supervision and at the appropriate dosage.īuspirone pregnancy and breastfeeding warnings (more detail) How should I take buspirone? It is not known whether buspirone passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. To make sure this medicine is safe for you, tell your doctor if you have any of these conditions:īuspirone is not expected to harm an unborn baby. ![]() ![]() MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, and tranylcypromine. ![]() A dangerous drug interaction could occur. You should not use buspirone if you are allergic to it.ĭo not use buspirone if you have taken an MAO inhibitor in the past 14 days. Related/similar drugs sertraline, alprazolam, fluoxetine, escitalopram, duloxetine, Lexapro, Zoloft Before taking this medicine ![]()
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